Bupropion, sold under the brand names Wellbutrin and Zyban among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. Bupropion is an effective antidepressant on its own, but it is also popular as an add-on medication in the cases of incomplete response to the first-line selective serotonin reuptake inhibitor (SSRI. Contraindicated (8) eliglustat. bupropion increases levels of eliglustat by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. If coadministered with strong or moderate CYP2D6 inhibitors, reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive and intermediate metabolizers; eliglustat is contraindiated if strong or moderate CYP2D6 inhibitors are given concomitantly. Smoking cessation. Bupropion is licensed for smoking cessation in both the UK and US and is recommended as a first line agent for smoking cessation ().Approximately 1 in 5 smokers successfully stop and remain non-smoking at one year with bupropion therapy (Table 1).The initial landmark trials of Hurt and Jorenby were conducted on healthy non-depressed patients and found comparable significant. Bupropion Hbr Tablet, Extended Release 24 Hr Common Brand(S): Aplenzin, Wellbutrin XL Generic Name(S): bupropion HBr View Free Coupon In the pediatric population, bupropion is used off-label for ADHD. This activity reviews the mechanism of action, adverse event profile, toxicity, dosing, pharmacodynamics, and monitoring of bupropion, pertinent for members of the interprofessional team for the treatment of patients with indications where bupropion has therapeutic value. Bupropion is an antidepressant medication that affects chemicals within the brain that nerves use to send messages to each other. These chemical messengers are called neurotransmitters. Many experts believe that depression is caused by an imbalance among the amounts of neurotransmitters that are released. Nerves, in a process referred to as reuptake, may recycle released neurotransmitters. Bupropion XL (Wellbutrin XL) is a moderately priced drug used to treat depression.This drug is slightly more popular than comparable drugs. It is available in brand and generic forms. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. Find patient medical information for bupropion HCl oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Bupropion, sold under the brand names Wellbutrin and Zyban among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. Bupropion is an effective antidepressant on its own, but it is also popular as an add-on medication in the cases of incomplete response to the first-line selective serotonin reuptake inhibitor (SSRI. The lowest GoodRx price for the most common version of bupropion is around $8.04, 62% off the average retail price of $21.28. Prescription Settings. generic. tablet. 75mg. 30 tablets. Share. Skip secondary navigation. Skip to: start of coupon list. Prices; Medicare; Drug Info; Side Effects; Images; Advertisement. Free Coupons. Prices as low as $8.04. Savings Clubs. A Savings Club is a program.